For Clinicians

This page brings together key clinical resources related to MSMDS and ACTA2-related conditions, with quick access to guidance, case-based insight, and downloadable materials.

Published Guidelines

Access published clinical guidelines covering ACTA2-related conditions, including variant-specific recommendations, vascular disease, and broader clinical management approaches. This content will be updated as new guidelines become available.

Clinical History and Management Recommendations of the Smooth Muscle Dysfunction Syndrome Due to ACTA2 Arginine 179 Alterations

European reference network for rare vascular diseases (VASCERN) consensus statement for the screening and management of patients with pathogenic ACTA2 variants

2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

2024 ESC Guidelines for the management of peripheral arterial and aortic diseases

Clinical Case Map

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Downloadable Materials

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